Abstract
Antagonism of the bradykinin B1 receptor represents a potential treatment for chronic pain and inflammation. Novel antagonists were designed that display low-nanomolar affinity for the human bradykinin B1 receptor and good bioavailability in the rat.
MeSH terms
-
Amides / chemical synthesis*
-
Amides / chemistry
-
Amides / pharmacology
-
Analgesics / chemical synthesis*
-
Analgesics / chemistry
-
Analgesics / pharmacology
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
-
Anti-Inflammatory Agents, Non-Steroidal / chemistry
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
-
Biological Availability
-
Bradykinin B1 Receptor Antagonists*
-
Cyclopropanes / chemical synthesis*
-
Cyclopropanes / chemistry
-
Cyclopropanes / pharmacology
-
Drug Design
-
Humans
-
Molecular Conformation
-
Pyridines / chemical synthesis*
-
Pyridines / chemistry
-
Pyridines / pharmacology
-
Rats
-
Stereoisomerism
-
Structure-Activity Relationship
Substances
-
Amides
-
Analgesics
-
Anti-Inflammatory Agents, Non-Steroidal
-
Bradykinin B1 Receptor Antagonists
-
Cyclopropanes
-
Pyridines